Xin Le,
You-fen Fan 
For correspondence:- You-fen Fan Email: lexin494133@163.com
Received: 7 January 2017 Accepted: 3 April 2017 Published: 30 May 2017
Citation: Le X, Fan Y. Healing effect of Sanguisorba officinalis L extract on second-degree burns in rats. Trop J Pharm Res 2017; 16(5):1045-1049 doi: 10.4314/tjpr.v16i5.11
© 2017 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate the healing effect of Sanguisorba officinalis L. extract (SOLE) on second-degree burns in rats.
Methods: Male Sprague Dawley rats, weighing 200 – 220 g, were subjected to deep second-degree skin burns by electrical scald instrument. The animals were divided into three groups as follows: (1) second-degree burns model (control), (2) burns model treated with 1 % silver sulfadiazine (SSD), and (3) burns model treated with SOLE. On days 3, 7 and 14, following administration of drug/extract, the wound area and histopathological changes of rat epidermis were evaluated in all the groups. Minimum inhibitory concentration (MIC) of SOLE on Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli was also assessed separately.
Results: On day 14, the mean wound area of SOLE treatment group (0.22 ± 0.05 cm2) was significantly smaller than that of control rats (2.67 ± 0.18 cm2, p < 0.01). Histological data indicate that inflammatory cells of burnt rats disappeared and were replaced by new granulation tissue by day 14 for the group treated with SOLE. The antibacterial results revealed that the MIC of SOLE for Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli was 3.5, 14.0 and 7.0 mg·mL-1, respectively.
Conclusion: Sanguisorba officinalis L. appears to be an effective medicinal herb for the treatment of second-degree burns
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